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A total of three % of active compound is excreted in urine as unchanged Lively substance. Tapentadol is Moreover metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (two %) by CYP2D6, that are further more metabolised by conjugation. Thus, active material metabolism mediated by cytochrome P450 method is of s